Are there significant interactions between oral combined contraceptives and non-rifampin antibiotics?
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- Answered 24 Oct 2019 Conflict of interest declaration: None The Faculty of Sexual and Reproductive Health have recently published “Drug Interactions with Hormonal Contraception” , this states: “Women should be advised about the importance of correct contraceptive practice during periods of illness According to recent evidence, most broad-spectrum antibiotics are non-enzyme-inducing and do not require any special precautions. No additional contraceptive precaution is required unless the antibiotics (and/or illness) cause vomiting or diarrhoea. Women starting enzyme-inducing drugs should be advised of potential interaction with hormonal contraception and be offered a reliable method unaffected by enzyme-inducers.” Drugs.com recently published “Antibiotics and Birth Control Pill Interactions: Fact or Fallacy?”  which reports: “According to the latest available studies, experts and women’s health providers, only one antibiotic - rifampin (Rifadin) - has been proven to make birth control less effective. Rifampin lowers the effectiveness by decreasing the birth control hormone levels (ethinyl estradiol and progestin) in women taking oral contraceptives.” There are a number of other studies out there that explore this issue and report, broadly, the same thing a selection are reported below [3, 4, 5]. Reference 1) https://www.fsrh.org/standards-and-guidance/current-clinical-guidance/drug-interactions/ 2) https://www.drugs.com/article/antibiotics-and-birth-control.html 3) https://www.ncbi.nlm.nih.gov/pubmed/28694152 4) https://www.ncbi.nlm.nih.gov/pubmed/29130574 5) https://www.ncbi.nlm.nih.gov/pubmed/12063491