Are genetics link to Polycystic ovarian syndrome in women of reproductive age
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- Answered 12 Nov 2019 Conflict of interest declaration: None I’ve interpreted this as asking about the genetics of PCOS. Given it’s about genetics I’m sure the reproductive age is irrelevant (unless I’m mis-interpreted the Q). At the simplest level the NHS have a document on causes of PCOS , this reports: “PCOS sometimes runs in families. If any relatives, such as your mother, sister or aunt, have PCOS, the risk of you developing it is often increased. This suggests there may be a genetic link to PCOS, although specific genes associated with the condition have not yet been identified.” The 2007 paper “The Genetic Basis of the Polycystic Ovary Syndrome: A Literature Review Including Discussion of PPAR-γ”  which includes the following in the abstract (note full-text available via the links below): “Familial clustering of PCOS has been consistently reported suggesting that genetic factors play a role in the development of the syndrome although PCOS cases do not exhibit a clear pattern of Mendelian inheritance.” In the 2018 book “Reproductive Medicine for Clinical Practice: Medical and Surgical Aspects” there is a section on the genetics of PCOS . Section 3.3 is relevant and highlights a lack of robust information. This theme continues in the 2019 paper “The Genetics of Polycystic Ovary Syndrome: An Overview of Candidate Gene Systematic Reviews and Genome-Wide Association Studies”  which states: "Familial clustering of PCOS symptoms is well documented, providing evidence for a genetic contribution to the condition.... ...Overall, the gene loci with the most robust findings were THADA, FSHR, INS-VNTR, and DENND1A, that now require validation. This overview also identified limitations of the current literature and important methodological considerations for future genetic studies. Much work remains to identify causal variants and functional relevance of genes associated with PCOS." References 1) https://www.nhs.uk/conditions/polycystic-ovary-syndrome-pcos/causes/ 2) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820621/ 3) http://bit.ly/2qQ0WOo 4) https://www.mdpi.com/2077-0383/8/10/1606